In what is viewed as the biggest regular season game for the Denver Broncos since 2015, they will host the AFC champion Kansas City Chiefs in Week 11. Patrick Mahomes is 19-2 in division road games in November or later. They will need to begin to change that narrative with a win here. A win could also go a long way towards securing their first AFC West title since the Peyton Manning era.
Kickoff is set for 2:25 p.m. Mile High time on Sunday, November 16, 2025 at Empower Field at Mile High in Denver, Colorado. You can watch the live stream of the game through FuboTV or on CBS. The game will be called by Jim Nantz (play-by-play), Tony Romo (analyst), and Tracy Wolfson (sideline). You can also check local Broncos radio network affiliate stations.
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Broncos vs. Chiefs score predictions
According to FanDuel, the Broncos are 4.5-point home underdogs to the Chiefs despite being at home and owning an 8-2 record. Quite the insult, but the Chiefs are the darlings of the NFL and battle-tested, so not surprising. Denver has plenty to prove before they get any love in these big games. Somehow, someway, I’m going to say the Broncos come out with the biggest win for this franchise in a decade.
Prediction: Broncos 23, Chiefs 19.